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The Role of Glycolysis in Shaping the Autoimmune Potential of Myelin-Reactive T Cells in the Course of Experimental Autoimmune Encephalomyelitis
By:Giuseppe Chiappetta
Published on 2019 by

Multiple sclerosis (MS) is an autoimmune disease of the central nervous system (CNS), where myelin-reactive T cells play a key role in the inflammatory events responsible for the formation of demyelinated lesions. Auto-reactive T cells are present in the immune repertoire of healthy people, but they only rarely cause autoimmunity. Exact mechanisms by which autoreactive T cells become pathogenic are still unclear. In order to investigate these mechanisms, we used a transgenic Lewis rat model containing endogenous myelin basic protein (MBP)-reactive CD4 T cells and we analyzed these cells in ...

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