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BAFF-R mutation
By:Christopher G. Mayne,The University of Wisconsin - Madison
Published on 2008 by ProQuest

Despite having 90% fewer splenic B cells than normal mice, A/WySnJ mice had an 18-fold increased frequency of splenocytes secreting IgM to dsDNA, and increased amounts of circulating IgM and IgG to dsDNA. A/WySnJ mice also displayed renal pathology characteristic of lupus, including proteinuria and glomerular capillary bed destruction. We genetically linked this autoimmunity to Bcmd-1, since congenic AW.Baffr +/+ mice carrying a wild-type allele developed none of these phenotypes.

This Book was ranked at 32 by Google Books for keyword autoimmune.

Book ID of BAFF-R mutation's Books is KK4IAQAAMAAJ, Book which was written byChristopher G. Mayne,The University of Wisconsin - Madisonhave ETAG "7kk5/mY/+g8"

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