Review Taking the STING Out of TLR‐driven Autoimmune Diseases: Good, Bad, Or Indifferent?.

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Taking the STING Out of TLR‐driven Autoimmune Diseases: Good, Bad, Or Indifferent?.
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Published on 2016 by

Abstract : Both endosomal and cytosolic‐nucleic acid–sensing receptors can detect endogenous ligands and promote autoimmunity and autoinflammation. These responses involve a complex interplay among and between the cytosolic and endosomal sensors involving both hematopoietic and radioresistant cells. Cytosolic sensors directly promote inflammatory responses through the production of type I IFNs and proinflammatory cytokines. Inflammation‐associated tissue damage can further promote autoimmune responses indirectly, as receptor‐mediated internalization of the resulting cell debris can activate endosomal Toll‐like receptors (TLR). Both endosomal and cytosolic receptors can also negatively regulate inflammatory responses. A better understanding of the factors and pathways that promote and constrain autoimmune diseases will have important implications for the development of agonists and antagonists that modulate these pathways. Abstract : Review of cytosolic and endosomal NA sensors in autoantibody production and systemic autoimmunity.

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