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Progranulin and Central Nervous System Disorders
By:Hideaki Hara,Masato Hosokawa,Shinsuke Nakamura,Takayoshi Shimohata,Masugi Nishihara
Published on 2019-03-25 by Springer

This book presents the latest knowledge on the roles of progranulin (PGRN) in normal physiology and pathology and explores the emerging significance of PGRN as a therapeutic target and biomarker in various CNS disorders, including frontotemporal lobe degeneration and other neurodegenerative diseases. Following initial recognition of the importance of PGRN in sexual differentiation of the developing brain and adult neurogenesis, it was subsequently discovered that PGRN acts as a chaperone of lysosomal enzymes and plays a crucial role in maintaining cellular protein homeostasis. It has also been found that sex steroids modulate the expression of PGRN and its trophic effects in the developing CNS and that PGRN directly or indirectly influences neural stem and progenitor cells. Against this background, deeper understanding of the molecular and functional properties of PGRN would provide fresh impetus for the development of mechanism-based therapeutic approaches for multiple disorders. Medications targeting the recovery of lysosomal function appear to hold particular promise in patients with neurodegenerative diseases resulting from PGRN insufficiency. In examining multiple aspects of this fascinating field, the book will be of high value for researchers and graduate students.

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Book ID of Progranulin and Central Nervous System Disorders's Books is nrqODwAAQBAJ, Book which was written byHideaki Hara,Masato Hosokawa,Shinsuke Nakamura,Takayoshi Shimohata,Masugi Nishiharahave ETAG "XvFs//BSAFo"

Book which was published by Springer since 2019-03-25 have ISBNs, ISBN 13 Code is 9789811361869 and ISBN 10 Code is 981136186X

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